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Article

RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.

Infection and immunity - 1 Nov 2004

Caimano Melissa J, Eggers Christian H, Hazlett Karsten R O, Radolf Justin D

Abstract excerpt

Borrelia burgdorferi, the Lyme disease spirochete, undergoes dramatic changes in antigenic composition as it cycles between its arthropod and mammalian hosts. A growing body of evidence suggests that these changes reflect, at least in part, the need for spirochetes to adapt to the physiological s...

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Identifiers

PMID: 15501774
DOI: 10.1128/IAI.72.11.6433-6445.2004
PMCID: PMC523033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15501774-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.PMID 15501774Read ↗

Analysis of the RpoS regulon in <i>Borrelia burgdorferi</i> in response to mammalian host signals provides insight into RpoS function during the enzootic cycleSemantic proximity Read ↗

Expression of <i>Borrelia burgdorferi</i> OspC and DbpA is controlled by a RpoN–RpoS regulatory pathwaySemantic proximity Read ↗

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Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.Semantic proximity Read ↗

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Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.Semantic proximity Read ↗

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