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Article

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.

mBio - 22 Aug 2017

Grove Arianna P, Liveris Dionysios, Iyer Radha, Petzke Mary, Rudman Joseph, Caimano Melissa J, Radolf Justin D, Schwartz Ira

Abstract excerpt

The alternative sigma factor RpoS plays a key role modulating gene expression in Borrelia burgdorferi, the Lyme disease spirochete, by transcribing mammalian host-phase genes and repressing σ70-dependent genes required within the arthropod vector. To identify cis regulatory elements involved in RpoS-dependent repression, we analyzed green fluorescent protein (GFP) transcriptional reporters containing portions of...

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Identifiers

PMID: 28830947
DOI: 10.1128/mBio.01204-17
PMCID: PMC5565969

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