Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity

21 Aug 2019

Abstract excerpt

Maintenance of Borrelia burgdorferi within its enzootic cycle requires a complex regulatory pathway involving the alternative  factors RpoN and RpoS and two ancillary trans-acting factors, BosR and Rrp2. Activation of this pathway occurs within ticks during the nymphal blood meal when RpoS, the effector  factor, transcribes genes required for tick transmission and mammalian infection. RpoS also exerts a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dermatological diseases and infestations
Share to Insect symbiosis and bacterial influences
Share to Vector-borne infectious diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31507550
DOI: 10.3389/fmicb.2019.01923

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche DiversityPMID 31507550Read ↗

Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferiSemantic proximity Read ↗

BosR and PlzA reciprocally regulate RpoS function to sustain Borrelia burgdorferi in ticks and mammalsSemantic proximity Read ↗

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogenSemantic proximity Read ↗

Two Distinct Mechanisms Govern RpoS-Mediated Repression of Tick-Phase Genes during Mammalian Host Adaptation by Borrelia burgdorferi, the Lyme Disease Spirochete.Semantic proximity Read ↗

Alternate Sigma Factor RpoS Is Required for the In Vivo-Specific Repression of<i>Borrelia burgdorferi</i>Plasmid lp54-Borne<i>ospA</i>and<i>lp6.6</i>GenesSemantic proximity Read ↗

Analysis of the RpoS regulon in <i>Borrelia burgdorferi</i> in response to mammalian host signals provides insight into RpoS function during the enzootic cycleSemantic proximity Read ↗

Expression of <i>Borrelia burgdorferi</i> OspC and DbpA is controlled by a RpoN–RpoS regulatory pathwaySemantic proximity Read ↗

Coupled induction of prophage and virulence factors during tick transmission of the Lyme disease spirocheteSemantic proximity Read ↗

Positive feedback regulation between RpoS and BosR in the Lyme disease pathogenSemantic proximity Read ↗

Transcriptomic insights on the virulence-controlling CsrA, BadR, RpoN, and RpoS regulatory networks in the Lyme disease spirochete.Semantic proximity Read ↗

RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinants.Semantic proximity Read ↗

Who is the BosR around here anyway?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.