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Article

A Positively Selected fur-R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression.

Infection and immunity - 16 Feb 2023

Loh John T, Struttmann Emily L, Favret Natalie, Harvey M Lorena, Pakala Suman B, Chopra Abha, McClain Mark S, Cover Timothy L

Abstract excerpt

Both Helicobacter pylori infection and a high-salt diet are risk factors for gastric cancer. We previously showed that a mutation in fur (encoding the ferric uptake regulator variant Fur-R88H) was positively selected in H. pylori strains isolated from experimentally infected Mongolian gerbils receiving a high-salt diet. In the present study, we report that continuous H. pylori growth in high-salt conditions in...

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Identifiers

PMID: 36633416
DOI: 10.1128/iai.00420-22
PMCID: PMC9933627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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