Article
High salt condition alters LPS synthesis and induces the emergence of drug resistance mutations in Helicobacter pylori.
Antimicrobial agents and chemotherapy - 8 Oct 2024
Huang Hongming, Yang Huang, Feng Shunhang, Zhang Xiaoyan, Chen Chu, Yan Hongyu, Li Rui, Liu Mengxin, Lin Juan, Wen Yancheng, She Feifei
Abstract excerpt
The burgeoning emergence of drug-resistant Helicobacter pylori strains poses a significant challenge to the clinical success of eradication therapies and is primarily attributed to mutations within drug-targeting genes that lead to antibiotic resistance. This study investigated the effect of high salt conditions on the occurrence of drug-resistance mutations in H. pylori. We found that high salt condition...
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