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Positive Selection of Mutations in the Helicobacter pylori katA 5' Untranslated Region in a Mongolian Gerbil Model of Gastric Disease.

Infection and immunity - 21 Jul 2022

Loh John T, Shuman Jennifer H B, Lin Aung Soe, Favret Natalie, Piazuelo M Blanca, Mallal Simon, Chopra Abha, McClain Mark S, Cover Timothy L

Abstract excerpt

To evaluate potential effects of gastric inflammation on Helicobacter pylori diversification and evolution within the stomach, we experimentally infected Mongolian gerbils with an H. pylori strain in which Cag type IV secretion system (T4SS) activity is controlled by a TetR/tetO system. Gerbils infected with H. pylori under conditions in which Cag T4SS activity was derepressed had significantly higher levels of...

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PMID: 35652648
DOI: 10.1128/iai.00004-22
PMCID: PMC9302185

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