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Article

Targeted design of drug binding sites in the main protease of SARS-CoV-2 reveals potential signatures of adaptation.

Biochemical and biophysical research communications - 28 May 2021

Padhi Aditya K, Tripathi Timir

Abstract excerpt

Several existing drugs are currently being tested worldwide to treat COVID-19 patients. Recent data indicate that SARS-CoV-2 is rapidly evolving into more transmissible variants. It is therefore highly possible that SARS-CoV-2 can accumulate adaptive mutations modulating drug susceptibility and hampering viral antigenicity. Thus, it is vital to predict potential non-synonymous mutation sites and predict the...

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PMID: 33813274
DOI: 10.1016/j.bbrc.2021.03.118
PMCID: PMC7997393

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