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Article

Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity?

Biochimica et biophysica acta. General subjects - 1 Mar 2018

Gaglione Rosa, Smaldone Giovanni, Di Girolamo Rocco, Piccoli Renata, Pedone Emilia, Arciello Angela

Abstract excerpt

BACKGROUND: Specific apolipoprotein A-I variants are associated to severe hereditary amyloidoses. The organ distribution of AApoAI amyloidosis seems to depend on the position of the mutation, since mutations in residues from 1 to 75 are mainly associated to hepatic and renal amyloidosis, while mutations in residues from 173 to 178 are mostly responsible for cardiac, laryngeal, and cutaneous amyloidosis. Molecular...

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Identifiers

PMID: 29174954
DOI: 10.1016/j.bbagen.2017.11.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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