The effect of long-range linkage disequilibrium on allele-frequency dynamics under stabilizing selection.

Abstract excerpt

Stabilizing selection on a polygenic trait reduces the trait's genetic variance by (i) generating correlations (linkage disequilibria) between opposite-effect alleles throughout the genome, and (ii) selecting against rare alleles at loci that affect the trait, eroding heterozygosity at these loci. Here, we show that the linkage disequilibria, which stabilizing selection generates on a rapid timescale, slow down...

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