Scalable linkage-disequilibrium-based selective sweep detection: a performance guide.

doi:10.1186/s13742-016-0114-9

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Article

Scalable linkage-disequilibrium-based selective sweep detection: a performance guide.

GigaScience - 1 Jan 2016

Alachiotis Nikolaos, Pavlidis Pavlos

Abstract excerpt

BACKGROUND: Linkage disequilibrium is defined as the non-random associations of alleles at different loci, and it occurs when genotypes at the two loci depend on each other. The model of genetic hitchhiking predicts that strong positive selection affects the patterns of linkage disequilibrium around the site of a beneficial allele, resulting in specific motifs of correlation between neutral polymorphisms that...

Topics

Algorithms
Alleles
Chromosomes, Human, Pair 1
Computational Biology
Computer Simulation
Gene Frequency
Genetics, Population
Genome, Human
Genotype
Humans
Linkage Disequilibrium
Models, Genetic
Mutation
Polymorphism, Single Nucleotide
Reproducibility of Results
Selection, Genetic
Sequence Analysis, DNA

Source

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Identifiers

PMID: 26862394
DOI: 10.1186/s13742-016-0114-9
PMCID: PMC4746822

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