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Article

Variance in estimated pairwise genetic distance under high versus low coverage sequencing: The contribution of linkage disequilibrium.

Theoretical population biology - 1 Oct 2017

Shpak Max, Ni Yang, Lu Jie, Müller Peter

Abstract excerpt

The mean pairwise genetic distance among haplotypes is an estimator of the population mutation rate θ and a standard measure of variation in a population. With the advent of next-generation sequencing (NGS) methods, this and other population parameters can be estimated under different modes of sampling. One approach is to sequence individual genomes with high coverage, and to calculate genetic distance over all...

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PMID: 28842178
DOI: 10.1016/j.tpb.2017.08.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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