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Article

Who's afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data.

Epigenetics & chromatin - 7 Jan 2023

Inkster Amy M, Wong Martin T, Matthews Allison M, Brown Carolyn J, Robinson Wendy P

Abstract excerpt

BACKGROUND: Many human disease phenotypes manifest differently by sex, making the development of methods for incorporating X and Y-chromosome data into analyses vital. Unfortunately, X and Y chromosome data are frequently excluded from large-scale analyses of the human genome and epigenome due to analytical complexity associated with sex chromosome dosage differences between XX and XY individuals, and the impact...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36609459
DOI: 10.1186/s13072-022-00477-0
PMCID: PMC9825011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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