GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate.

doi:10.1037/a0038350

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Article

GRIK1 genotype and daily expectations of alcohol's positive effects moderate the reduction of heavy drinking by topiramate.

Experimental and clinical psychopharmacology - 1 Dec 2014

Kranzler Henry R, Armeli Stephen, Tennen Howard, Gelernter Joel, Covault Jonathan

Abstract excerpt

Using retrospective reports obtained during treatment visits in 138 heavy drinkers, we found that topiramate's reduction of heavy drinking was moderated by a polymorphism (rs2832407) in GRIK1, which encodes the GluK1 kainate subunit (Kranzler et al., 2014a). A subsequent analysis of that 12-week topiramate treatment trial showed similar effects of medication and genotype on daily drinking reports obtained via...

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PMID: 25436841
DOI: 10.1037/a0038350
PMCID: PMC4251491

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GRIK1

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