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Article

A homozygous loss-of-function variant in the MPO gene is associated with generalized pustular psoriasis.

The Journal of dermatology - 1 May 2023

Onitsuka Mami, Farooq Muhammad, Iqbal Muhammad Nasir, Yasuno Shuichiro, Shimomura Yutaka

Abstract excerpt

Generalized pustular psoriasis (GPP) is a rare form of psoriasis, which is characterized by sudden onset of repeated erythema and pustule formation with generalized inflammation. Recent advances in molecular genetics have led to the identification of several genes associated with GPP, including IL36RN, CARD14, AP1S3, SERPINA3, and MPO. Of these, only limited cases of GPP have been reported to carry mutations in...

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PMID: 36585391
DOI: 10.1111/1346-8138.16700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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