Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.

Journal of human genetics - 1 Jun 2023

Liu Yaqin, Li Hongmei, Meng Shasha, Xu Yunfei, Ni Sili, Sun Yanan, Zhou Weihui

Abstract excerpt

Generalized pustular psoriasis (GPP) is an autoinflammatory skin disease whose pathogenesis has not yet been fully elucidated. Alpha-1-antichymotrypsin(ACT) is a protein encoded by the SERPINA3 gene and an inhibitor of cathepsin G. One study of a European sample suggested that the loss of ACT function caused by SERPINA3 mutation is implicated in GPP. However, the role of SERPINA3 in the pathogenesis of GPP in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Child
Share to Interleukins
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Psoriasis

Share to Serpins

Share to Skin Diseases

Source

Identifiers

PMID: 36828876
DOI: 10.1038/s10038-023-01139-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Newly revealed variants of SERPINA3 in generalized pustular psoriasis attenuate inhibition of ACT on cathepsin G.PMID 36828876Read ↗

SERPINB3, Adult-Onset Immunodeficiency, and Generalized Pustular Psoriasis.Semantic proximity Read ↗

Genetics of Generalized Pustular Psoriasis: Current Understanding and Implications for Future Therapeutics.Semantic proximity Read ↗

An update on genetic basis of generalized pustular psoriasis (Review).Semantic proximity Read ↗

Pustular psoriasis as an autoinflammatory keratinization disease (AiKD): Genetic predisposing factors and promising therapeutic targets.Semantic proximity Read ↗

SERPINA1, generalized pustular psoriasis, and adult-onset immunodeficiency.Semantic proximity Read ↗

AP1S3 Mutations Are Associated with Pustular Psoriasis and Impaired Toll-like Receptor 3 TraffickingSemantic proximity Read ↗

Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese PopulationSemantic proximity Read ↗

Prevalence, comorbidities and mortality of generalized pustular psoriasis: A literature review.Semantic proximity Read ↗

Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist DegradationSemantic proximity Read ↗

Mutations in SERPINB7, encoding a member of the serine protease inhibitor superfamily, cause Nagashima-type palmoplantar keratosis.Semantic proximity Read ↗

Mutations in PGRN gene associated with the risk of psoriasis in Pakistan: a case control study.Semantic proximity Read ↗

Loss-of-Function Variants in SERPINA12 Underlie Autosomal Recessive Palmoplantar Keratoderma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.