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Article

Down-regulated long non-coding RNA PVT1 contributes to gestational diabetes mellitus and preeclampsia via regulation of human trophoblast cells

15 Oct 2019

Abstract excerpt

OBJECTIVE: We aimed to explore the expression level and biological function of lncRNA PVT1 in human trophoblast cells. METHODS: The expression levels of PVT1 in cancer cell lines, HTR8/SVneo cell, HUVEC cell, the maternal placenta of GDM patients, PE patients and normal pregnancy were detected by qRT-PCR. The cell culture, cell transfection, CCK-8 assay, flow cytometry, wound scratch assay and transwell were...

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PMID: 31627090
DOI: 10.1016/j.biopha.2019.109501

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