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Article

Estradiol promotes trophoblast viability and invasion by activating SGK1

13 Jun 2019

Abstract excerpt

BACKGROUND: 17β-Estradiol (E2) is a critical regulator of trophoblast function during pregnancy. Serum- and glucocorticoid-inducible kinase (SGK1) has been shown to regulate specific cellular targets downstream of E2. However, whether and how SGK1 directly mediates the regulatory effects of E2 on trophoblasts functions remain unknown. METHODS: SGK1 expression in human villous samples and serum E2 levels were...

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PMID: 31203134
DOI: 10.1016/j.biopha.2019.109092

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