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Significance of anti‐desmocollin autoantibodies in pemphigus

28 Dec 2022

Abstract excerpt

The major autoantigens for pemphigus are desmogleins (Dsgs), cell-cell adhesive structure proteins, one of the desmosomal cadherins. Recent progress in molecular biology has revealed that IgG autoantibodies of classical pemphigus react with Dsg1 or Dsg3. Desmocollins (Dscs) also belong to the cadherin supergene family that provides structure to the desmosomes and play an important role in cell-to-cell adhesion....

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PMID: 36578135
DOI: 10.1111/1346-8138.16660

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