Article
Mitotic count is prognostic in IDH mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trial 26053 (CATNON) and EORTC trial 22033-26033.
Neuro-oncology - 3 Aug 2023
Kros Johan M, Rushing Elisabeth, Uwimana Aimé L, Hernández-Laín Aurelio, Michotte Alex, Al-Hussaini Maysa, Bielle Franck, Mawrin Christian, Marucci Gianluca, Tesileanu C Mircea S, Stupp Roger, Baumert Brigitta, van den Bent Martin, French Pim J, Gorlia Thierry
Abstract excerpt
BACKGROUND: Gliomas with IDH1/2 mutations without 1p19q codeletion have been identified as the distinct diagnostic entity of IDH mutant astrocytoma (IDHmut astrocytoma). Homozygous deletion of Cyclin-dependent kinase 4 inhibitor A/B (CDKN2A/B) has recently been incorporated in the grading of these tumors. The question of whether histologic parameters still contribute to prognostic information on top of the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.