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Article

Aldehyde dehydrogenase 1A3 (ALDH1A3) is regulated by autophagy in human glioblastoma cells.

Cancer letters - 28 Mar 2018

Wu Wei, Schecker Johannes, Würstle Sylvia, Schneider Fabian, Schönfelder Martin, Schlegel Jürgen

Abstract excerpt

Aldehyde dehydrogenase is a polymorphic enzyme, which responsible for the oxidation of aldehydes. It has been shown that ALDH1A3 is expressed in human glioblastomas and that its expression correlates with a worse prognosis. In our present study ALDH1A3 expression was associated with resistance against Temozolomide (TMZ) treatment and sensitivity could be re-established in ALDH1A3 knockout cells. TMZ treatment at...

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Source

Identifiers

PMID: 29306018
DOI: 10.1016/j.canlet.2017.12.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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