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Article

gldc Is Essential for Renal Progenitor Patterning during Kidney Development

12 Dec 2022

Abstract excerpt

The glycine cleavage system (GCS) is a complex located on the mitochondrial membrane that is responsible for regulating glycine levels and contributing one-carbon units to folate metabolism. Congenital mutations in GCS components, such as glycine decarboxylase (gldc), cause an elevation in glycine levels and the rare disease, nonketotic hyperglycinemia (NKH). NKH patients suffer from pleiotropic symptoms...

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PMID: 36551976
DOI: 10.3390/biomedicines10123220

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