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Article

Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia.

Journal of inherited metabolic disease - 1 Nov 2020

Leung Kit-Yi, De Castro Sandra C P, Santos Chloe, Savery Dawn, Prunty Helen, Gold-Diaz Diana, Bennett Stuart, Heales Simon, Copp Andrew J, Greene Nicholas D E

Abstract excerpt

Glycine abundance is modulated in a tissue-specific manner by use in biosynthetic reactions, catabolism by the glycine cleavage system (GCS), and excretion via glycine conjugation. Dysregulation of glycine metabolism is associated with multiple disorders including epilepsy, developmental delay, and birth defects. Mutation of the GCS component glycine decarboxylase (GLDC) in non-ketotic hyperglycinemia (NKH)...

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PMID: 32743799
DOI: 10.1002/jimd.12295
PMCID: PMC8436753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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