Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.

doi:10.1126/science.282.5392.1321

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Article

Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.

Science (New York, N.Y.) - 13 Nov 1998

Feng G, Tintrup H, Kirsch J, Nichol M C, Kuhse J, Betz H, Sanes J R

Abstract excerpt

Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Molecular cloning revealed the similarity of gephyrin to prokaryotic and invertebrate proteins essential for synthesizing a cofactor required for activity of molybdoenzymes. Gene targeting in mice s...

Topics

Animals
Animals, Newborn
Brain
Carrier Proteins
Chimera
Coenzymes
Gene Targeting
Glycine
Humans
Membrane Proteins
Metalloproteins
Mice
Molybdenum
Molybdenum Cofactors
Motor Neurons
Oxidoreductases Acting on Sulfur Group Donors
Phenotype
Pteridines

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Open in PubMed

Identifiers

PMID: 9812897
DOI: 10.1126/science.282.5392.1321

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9812897-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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