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Article

Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.

Science (New York, N.Y.) - 13 Nov 1998

Feng G, Tintrup H, Kirsch J, Nichol M C, Kuhse J, Betz H, Sanes J R

Abstract excerpt

Glycine receptors are anchored at inhibitory chemical synapses by a cytoplasmic protein, gephyrin. Molecular cloning revealed the similarity of gephyrin to prokaryotic and invertebrate proteins essential for synthesizing a cofactor required for activity of molybdoenzymes. Gene targeting in mice showed that gephyrin is required both for synaptic clustering of glycine receptors in spinal cord and for molybdoenzyme...

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PMID: 9812897
DOI: 10.1126/science.282.5392.1321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity.PMID 9812897Read ↗

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A zebrafish gephyrinb mutant distinguishes synaptic and enzymatic functions of Gephyrin.Semantic proximity Read ↗

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The glycinergic system in human startle disease: a genetic screening approachSemantic proximity Read ↗

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