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Radiotherapy and radiosensitivity syndromes in DNA repair gene mutations.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2022

Lohynská R, Pechačová Z, Mazaná E, Čejková J, Nováková-Jirešová A, Hornová J, Langová M

Abstract excerpt

BACKGROUND: Ionizing radiation DNA damage is the main mechanism of radiotherapy (RT) action and the outcome of treatment and healthy tissue toxicity is influenced by a number of external and internal factors, including mutations in DNA damage recognition and repair. Disorders of DNA repair may result in increased sensitivity to cancer treatment. PURPOSE: The mechanism of DNA repair and an overview of genetic...

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PMID: 35459336
DOI: 10.48095/ccko2022119

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