Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.

doi:10.1038/s41586-023-06618-z

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.

Nature - 1 Jan 2024

Barrie William, Yang Yaoling, Irving-Pease Evan K, Attfield Kathrine E, Scorrano Gabriele, Jensen Lise Torp, Armen Angelos P, Dimopoulos Evangelos Antonios, Stern Aaron, Refoyo-Martinez Alba, Pearson Alice, Ramsøe Abigail, Gaunitz Charleen, Demeter Fabrice, Jørkov Marie Louise S, Møller Stig Bermann, Springborg Bente, Klassen Lutz, Hyldgård Inger Marie, Wickmann Niels, Vinner Lasse, Korneliussen Thorfinn Sand, Allentoft Morten E, Sikora Martin, Kristiansen Kristian, Rodriguez Santiago, Nielsen Rasmus, Iversen Astrid K N, Lawson Daniel J, Fugger Lars, Willerslev Eske

Abstract excerpt

Multiple sclerosis (MS) is a neuro-inflammatory and neurodegenerative disease that is most prevalent in Northern Europe. Although it is known that inherited risk for MS is located within or in close proximity to immune-related genes, it is unknown when, where and how this genetic risk originated1. Here, by using a large ancient genome dataset from the Mesolithic period to the Bronze Age2, along with new Medieval...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Datasets as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetics, Medical

Share to Grassland

Share to History, Ancient

Share to History, Medieval

Share to Human Migration

Share to Life Style

Share to Neurodegenerative Diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 38200296
DOI: 10.1038/s41586-023-06618-z
PMCID: PMC10781639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Elevated genetic risk for multiple sclerosis emerged in steppe pastoralist populations.PMID 38200296Read ↗

Elevated genetic risk for multiple sclerosis originated in Steppe Pastoralist populationsSemantic proximity Read ↗

The evolutionary origins of multiple sclerosis.Semantic proximity Read ↗

Environmental and genetic risk factors for MS: an integrated reviewSemantic proximity Read ↗

Genetic Risk in Multiple Sclerosis: Susceptibility, Modifiers and Unresolved QuestionsSemantic proximity Read ↗

Integrated determinants of multiple sclerosis susceptibility: Genetics, environment, infection and the microbiota.Semantic proximity Read ↗

The genetics of multiple sclerosis: an up-to-date review.Semantic proximity Read ↗

Genome‐wide association studies of multiple sclerosisSemantic proximity Read ↗

The Role of Selection and Migration in the Evolution of (Auto)Immunity Genes.Semantic proximity Read ↗

The genetic architecture of multiple sclerosis in 2026: From susceptibility to disease progression.Semantic proximity Read ↗

Multiple sclerosis genetics--is the glass half full, or half empty?Semantic proximity Read ↗

The Genetics of Multiple Sclerosis: From 0 to 200 in 50 Years.Semantic proximity Read ↗

Risk factors of multiple sclerosis: insights from the United Arab Emirates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.