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Transcriptomic Signatures of Human Immunodeficiency Virus Post-Treatment Control

21 Dec 2022

Abstract excerpt

The findings presented here provide new insights into how HIV and cellular gene expression change after stopping ART in both noncontrollers and posttreatment controllers. Posttreatment control is associated with an early ability to limit increases in multiply-spliced HIV RNA, a delayed (and presumably immune-mediated) ability to reverse an initial rise in processive/completed HIV transcripts, and multiple...

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PMID: 36541802
DOI: 10.1128/jvi.01254-22

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