Article
Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia.
Leukemia - 1 Mar 2023
Jiang Kailong, Li Xuemei, Wang Chang, Hu Xiaobei, Wang Peipei, Tong Lexian, Tu Yutong, Chen Beijing, Jin Tingting, Wang Tao, Wang Hanlin, Han Yubing, Gui Renzhao, Yang Jianmin, Liu Tao, Li Jia, Zhou Yubo
Abstract excerpt
FLT3 inhibitors (FLT3i) are widely used for the treatment of acute myeloid leukemia (AML), but adaptive and acquired resistance remains a primary challenge. Inhibitors simultaneously blocking adaptive and acquired resistance are highly demanded. Here, we observed the potential of CHK1 inhibitors...
Topics
- Animals
- Dogs
- Humans
- Apoptosis
- Cell Line, Tumor
- Drug Resistance, Neoplasm
- fms-Like Tyrosine Kinase 3
- Leukemia, Myeloid, Acute
- Mutation
- Protein Kinase Inhibitors