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Article

Investigational drugs targeting FLT3 for leukemia.

Expert opinion on investigational drugs - 1 Oct 2009

Ustun Celalettin, DeRemer David L, Jillella Anand P, Bhalla Kapil N

Abstract excerpt

FMS-like tyrosine kinase-3 (FLT3) is a member of the class III membrane receptor tyrosine kinase family and is important in survival, proliferation and differentiation of hematopoietic cells. FLT3 is mutated in approximately 30% of acute myelogenous leukemia patients. These mutations involve internal tandem duplications in the juxtamembrane domain of the receptor and tyrosine kinase point mutations in the...

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Source

Identifiers

PMID: 19671038
DOI: 10.1517/13543780903179278

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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