Article
Next-generation sequencing of paired tyrosine kinase inhibitor-sensitive and -resistant EGFR mutant lung cancer cell lines identifies spectrum of DNA changes associated with drug resistance.
Genome research - 1 Sept 2013
Jia Peilin, Jin Hailing, Meador Catherine B, Xia Junfeng, Ohashi Kadoaki, Liu Lin, Pirazzoli Valentina, Dahlman Kimberly B, Politi Katerina, Michor Franziska, Zhao Zhongming, Pao William
Abstract excerpt
Somatic mutations in kinase genes are associated with sensitivity of solid tumors to kinase inhibitors, but patients with metastatic cancer eventually develop disease progression. In EGFR mutant lung cancer, modeling of acquired resistance (AR) with drug-sensitive cell lines has identified clinically relevant EGFR tyrosine kinase inhibitor (TKI) resistance mechanisms such as the second-site mutation, EGFR T790M,...
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