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Article

Longitudinal single-cell RNA model aids prediction of EGFR-TKI resistance.

Carcinogenesis - 4 Sept 2025

Hou Guoxin, Lu Zhimin, Zeng Dongqiang, Chen Qican, Cheng Subing, Song Binbin

Abstract excerpt

Resistance is inevitable and a major challenge in treating lung adenocarcinoma (LUAD) patients with EGFR mutations. This study aimed to investigate the mechanism of EGFR-TKI resistance in LUAD using longitudinal single-cell RNA sequencing (scRNA-seq) data. We collected tumour samples of LUAD patients before and after EGFR inhibitor treatment and performed single-cell RNA sequencing. We used machine learning...

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Share to Adenocarcinoma of Lung
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Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40739818
DOI: 10.1093/carcin/bgaf038

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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