Article
The performance of multi-gene panels for breast/ovarian cancer predisposition.
Clinica chimica acta; international journal of clinical chemistry - 15 Jan 2023
Nunziato Marcella, Scaglione Giovanni Luca, Di Maggio Federica, Nardelli Carmela, Capoluongo Ettore, Salvatore Francesco
Abstract excerpt
BRCA1 and BRCA2 are the most mutated genes in breast cancer. We analyzed 48 breast cancer subjects using two methods that differ in terms of number of genes investigated and strategy used (primers: Panel A - 12 genes - vs probes: Panel B - 48 genes). Both the panels and procedures identified "pathogenic" or "likely pathogenic" variants in TP53, ATM, CHEK2 and BARD1 besides BRCA1 and BRCA2. Panel B identified two...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.