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Article

Optimizing the identification of risk-relevant mutations by multigene panel testing in selected hereditary breast/ovarian cancer families.

Cancer medicine - 1 Jan 2018

Coppa Anna, Nicolussi Arianna, D'Inzeo Sonia, Capalbo Carlo, Belardinilli Francesca, Colicchia Valeria, Petroni Marialaura, Zani Massimo, Ferraro Sergio, Rinaldi Christian, Buffone Amelia, Bartolazzi Armando, Screpanti Isabella, Ottini Laura, Giannini Giuseppe

Abstract excerpt

The introduction of multigene panel testing for hereditary breast/ovarian cancer screening has greatly improved efficiency, speed, and costs. However, its clinical utility is still debated, mostly due to the lack of conclusive evidences on the impact of newly discovered genetic variants on cancer risk and lack of evidence-based guidelines for the clinical management of their carriers. In this pilot study, we...

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Source

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Identifiers

PMID: 29271107
DOI: 10.1002/cam4.1251
PMCID: PMC5773970

Genes

BRCA1
ATM
BRCA2
CHEK2
RAD50

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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