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Article

Krt14 and Krt15 differentially regulate regenerative properties and differentiation potential of airway basal cells.

JCI insight - 24 Jan 2023

Ievlev Vitaly, Lynch Thomas J, Freischlag Kyle W, Gries Caitlyn B, Shah Anit, Pai Albert C, Ahlers Bethany A, Park Soo, Engelhardt John F, Parekh Kalpaj R

Abstract excerpt

Keratin expression dynamically changes in airway basal cells (BCs) after acute and chronic injury, yet the functional consequences of these changes on BC behavior remain unknown. In bronchiolitis obliterans (BO) after lung transplantation, BC clonogenicity declines, which is associated with a switch from keratin15 (Krt15) to keratin14 (Krt14). We investigated these keratins' roles using Crispr-KO in vitro and in...

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Identifiers

PMID: 36512409
DOI: 10.1172/jci.insight.162041
PMCID: PMC9977304

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