Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study.

Psychopharmacology - 1 Jan 2026

Li Xiang, Wang Jianyi

Abstract excerpt

AIMS: Depression is associated with numerous metabolic pathway abnormalities, and several studies have suggested a link between depression and branched chain amino acids (BCAAs) metabolic disorders. However, the precise causality and direction remain inconclusive. Consequently, this study aims to ascertain the relationship between the risk of depression and BCAAs levels using two-sample Mendelian randomization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids, Branched-Chain
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Linkage Disequilibrium

Share to Major Depressive Disorder

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Valine

Source

Identifiers

PMID: 40663140
DOI: 10.1007/s00213-025-06851-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Branched-chain amino acids and risk of major depressive disorder: a Mendelian randomization and colocalization study.PMID 40663140Read ↗

Associations between serum amino acids and genetic liability to depression in the LURIC cohort.Semantic proximity Read ↗

The Metabolome-Wide Signature of Major Depressive DisorderSemantic proximity Read ↗

Clustering of major depressive disorder genetic instruments identifies distinct and directionally opposing effects on cardiometabolic riskSemantic proximity Read ↗

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization studySemantic proximity Read ↗

The causal effect of folate on major depressive disorder: Mendelian randomization, LDSC, and colocalization analysis.Semantic proximity Read ↗

Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study.Semantic proximity Read ↗

Omega-3 fatty acids and major depression: a Mendelian randomization study.Semantic proximity Read ↗

Unraveling the genetic interplay and therapeutic potentials between major depressive disorder and metabolic syndrome: multi-ancestry and multi-trait genome-wide association analyses.Semantic proximity Read ↗

Characteristics of gut microbiota and metabolic phenotype in patients with major depressive disorder based on multi-omics analysis.Semantic proximity Read ↗

Association of Circulating Branched-Chain Amino Acids with Cardiovascular Diseases: A Mendelian Randomization Study.Semantic proximity Read ↗

Differential associations of various depression-related phenotypes with cardiometabolic risks: Identification of shared genetic factors and implications for drug repositioningSemantic proximity Read ↗

Unravelling the role of alanine in mental disorders: a Mendelian randomisation study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.