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Article

Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen

1 Jul 2012

Abstract excerpt

Breast cancer (BC) is a disease with diverse tumor heterogeneity, which challenges conventional approaches to develop biomarkers for early detection and prognosis. To identify effective biomarkers, we performed a genome-wide screen for functional methylation changes in BC, i.e., genes silenced by promoter hypermethylation, using a functionally proven gene expression approach. A subset of candidate hypermethylated...

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PMID: 22647880
DOI: 10.4161/epi.20445

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