Germline findings in patients with advanced malignancies screened with paired blood-tumour testing for personalised treatment approaches.

doi:10.1016/j.ejca.2022.11.003

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Article

Germline findings in patients with advanced malignancies screened with paired blood-tumour testing for personalised treatment approaches.

European journal of cancer (Oxford, England : 1990) - 1 Jan 2023

Roggia Cristiana, Armeanu-Ebinger Sorin, Gschwind Axel, Seibel-Kelemen Olga, Hertler Sonja, Faust Ulrike, Liebmann Alexandra, Haack Tobias B, Neumann Manuela, Bonzheim Irina, Forschner Andrea, Kopp Hans-Georg, Herster Franziska, Hartkopf Andreas, Bitzer Michael, Malek Nisar P, Brecht Ines B, Ruhm Kristina, Möller Yvonne, Löwenheim Hubert, Ossowski Stephan, Rieß Olaf H, Schroeder Christopher

Abstract excerpt

BACKGROUND: Sequencing of tumour tissue with comprehensive gene panels is increasingly used to guide treatment in precision oncology. Analysis of tumour-normal pairs allows in contrast to tumour-only assessment direct discrimination between somatic and germline alterations, which might have important implications not only for the patients but also their families. METHODS: We performed tumour normal sequencing...

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PMID: 36495689
DOI: 10.1016/j.ejca.2022.11.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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