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Article

Computational optimisation of targeted DNA sequencing for cancer detection.

Scientific reports - 3 Dec 2013

Martinez Pierre, McGranahan Nicholas, Birkbak Nicolai Juul, Gerlinger Marco, Swanton Charles

Abstract excerpt

Despite recent progress thanks to next-generation sequencing technologies, personalised cancer medicine is still hampered by intra-tumour heterogeneity and drug resistance. As most patients with advanced metastatic disease face poor survival, there is need to improve early diagnosis. Analysing circulating tumour DNA (ctDNA) might represent a non-invasive method to detect mutations in patients, facilitating early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24296834
DOI: 10.1038/srep03309
PMCID: PMC6506443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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