Article
Therapeutic Implications of Germline Testing in Patients With Advanced Cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 20 Aug 2021
Stadler Zsofia K, Maio Anna, Chakravarty Debyani, Kemel Yelena, Sheehan Margaret, Salo-Mullen Erin, Tkachuk Kaitlyn, Fong Christopher J, Nguyen Bastien, Erakky Amanda, Cadoo Karen, Liu Ying, Carlo Maria I, Latham Alicia, Zhang Hongxin, Kundra Ritika, Smith Shaleigh, Galle Jesse, Aghajanian Carol, Abu-Rustum Nadeem, Varghese Anna, O'Reilly Eileen M, Morris Michael, Abida Wassim, Walsh Michael, Drilon Alexander, Jayakumaran Gowtham, Zehir Ahmet, Ladanyi Marc, Ceyhan-Birsoy Ozge, Solit David B, Schultz Nikolaus, Berger Michael F, Mandelker Diana, Diaz Luis A, Offit Kenneth, Robson Mark E
Abstract excerpt
PURPOSE: Tumor mutational profiling is increasingly performed in patients with advanced cancer. We determined the extent to which germline mutation profiling guides therapy selection in patients with advanced cancer. METHODS: Patients with cancer undergoing tumor genomic profiling were prospectively consented for germline cancer predisposition gene analysis (2015-2019). In patients harboring germline likely...
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