Article
Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients.
Journal of human genetics - 1 Feb 2023
Matsubayashi Hiroyuki, Todaka Akiko, Kawakami Takeshi, Hamauchi Satoshi, Yokota Tomoya, Higashigawa Satomi, Kiyozumi Yoshimi, Harada Rina, Kado Nobuhiro, Nishimura Seiichiro, Ishiwatari Hirotoshi, Sato Junya, Niiya Fumitaka, Ono Hiroyuki, Sugiura Teiichi, Sasaki Keiko, Yasui Hirofumi, Yamazaki Kentaro
Abstract excerpt
In 2021, Japan's national health insurance made germline BRCA (g.BRCA) testing available to unresectable pancreatic cancer (PC) patients as a companion diagnostic (CD) of the PARP inhibitor. This study investigated the incidence of the g.BRCA variant (g.BRCAv.) and the status of the genetic medicine associated with its testing. A total of 110 PC patients underwent the testing, five of whom (4.5%) had a...
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