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Real-world genome profiling in Japanese patients with pancreatic ductal adenocarcinoma focusing on HRD implications.

Cancer science - 1 Nov 2024

Doi Toshifumi, Ishikawa Takeshi, Sakakida Tomoki, Itani Junichiro, Sone Daiki, Morita Ryuichi, Kataoka Seita, Miyake Hayato, Seko Yuya, Yamaguchi Kanji, Moriguchi Michihisa, Sogame Yoshio, Konishi Hideyuki, Murashima Kyoko, Iwasaku Masahiro, Takayama Koichi, Itoh Yoshito

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) poses significant challenges due to its high mortality, making it a critical area of research. This retrospective observational study aimed to analyze real-world data from comprehensive genome profiling (CGP) of Japanese patients with PDAC, mainly focusing on differences in gene detection rates among panels and the implications for homologous recombination deficiency (HRD)...

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Identifiers

PMID: 39315592
DOI: 10.1111/cas.16329
PMCID: PMC11531956

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