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Article

Overexpression of Rhodopsin or Its Mutants Leads to Energy Metabolism Dysfunction in 661w Cells.

Investigative ophthalmology & visual science - 1 Dec 2022

Liu Yang, Wang Xin, Gong Ruowen, Xu Gezhi, Zhu Min

Abstract excerpt

Purpose: Retinitis pigmentosa (RP) is a heterogeneous group of inherited disorders characterized by photoreceptor degeneration. The rhodopsin gene (RHO) is the most frequent cause of autosomal dominant RP (ADRP), yet it remains unclear how RHO mutations cause heterogeneous phenotypes. Energy failure is a main cause of the secondary cone death during RP progression; however, its role in primary rod death induced...

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Identifiers

PMID: 36469028
DOI: 10.1167/iovs.63.13.2
PMCID: PMC9730732

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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