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C1QBP regulates mitochondrial plasticity to impact tumor progression and antitumor immune response

17 Nov 2022

Abstract excerpt

Mitochondrial plasticity including mitochondrial dynamics, metabolic flexibility, and mitochondrial quality control, impact tumor cells' progression and determine immune cells' fate. Complement C1q binding protein (C1QBP) plays an indispensable role through regulating mitochondrial morphology, metabolism, and autophagy. C1QBP promotes mitochondrial plasticity to impact tumor metastasis and their therapeutic...

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PMID: 36467687
DOI: 10.3389/fphys.2022.1012112

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