Article
Matrix stiffness-mediated effects on stemness characteristics occurring in HCC cells.
Oncotarget - 31 May 2016
You Yang, Zheng Qiongdan, Dong Yinying, Xie Xiaoying, Wang Yaohui, Wu Sifan, Zhang Lan, Wang Yingcong, Xue Tongchun, Wang Zhiming, Chen Rongxin, Wang Yanhong, Cui Jiefeng, Ren Zhenggang
Abstract excerpt
Matrix stiffness as an important physical attribute of extracellular matrix exerts significant impacts on biological behaviors of cancer cells such as growth, proliferation, motility, metabolism and invasion. However, its influence on cancer stemness still remains elusive. Here, we explore whether matrix stiffness-mediated effects on stemness characteristics occur in HCC cells. As the substrate stiffness...
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