Article
Methylene tetrahydrofolate reductase gene mutation in sickle cell anaemia patients in Lagos, Nigeria.
The Pan African medical journal - 1 Jan 2019
Adelekan Oluwaseun Olabisi, Uche Ebele Ifeyinwa, Balogun Taiwo Modupe, Osunkalu Vincent Oluseye, Akinbami Akinsegun Abduljaleel, Ismail Kamal Ayobami, Badiru Mulikat Adesola, Dosunmu Adedoyin Owolabi, Kamson Omolara Risqat
Abstract excerpt
INTRODUCTION: The significant causes of mortality among individuals with sickle cell anaemia (SCA) such as acute chest syndrome and cerebrovascular disease are related to vascular occlusion. Polymorphisms of the methylene tetrahydrofolate reductase (MTHFR) gene in persons with sickle cell anaemia have been suggested as a potential risk for vaso-occlusive events, with the C677T and A1298C polymorphisms being the...
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