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Article

Investigating the association between COL1A1 and COL3A1 gene variants and knee joint laxity and ligament measurements.

Clinical biomechanics (Bristol, Avon) - 1 Dec 2022

Beckley Samantha, Dey Roopam, Stinton Shaun, van der Merwe Willem, Branch Thomas, September Alison V, Posthumus Mike, Collins Malcolm

Abstract excerpt

BACKGROUND: Joint laxity is a multifactorial phenotype with a heritable component. Type I collagen gene (COL1A1) mutations cause connective tissue disorders with joint hypermobility as a clinical feature, while variants within COL1A1 and type III collagen gene (COL3A1) are associated with musculoskeletal injuries. The aim of this study was to investigate whether COL1A1 and COL3A1 variants are associated with...

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Identifiers

PMID: 36436321
DOI: 10.1016/j.clinbiomech.2022.105822

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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