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Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma

25 Nov 2022

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with poor prognosis. Proteogenomic characterization and integrative proteomic analysis provide a functional context to annotate genomic abnormalities with prognostic value. METHODS: We performed an integrated multi-omics analysis, including whole-exome sequencing, RNA-seq, proteomic, and phosphoproteomic analysis of 217 PDAC tumors with...

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PMID: 36434634
DOI: 10.1186/s13045-022-01384-3

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