Article
Proteogenomic characterization of pancreatic ductal adenocarcinoma.
Cell - 16 Sept 2021
Cao Liwei, Huang Chen, Cui Zhou Daniel, Hu Yingwei, Lih T Mamie, Savage Sara R, Krug Karsten, Clark David J, Schnaubelt Michael, Chen Lijun, da Veiga Leprevost Felipe, Eguez Rodrigo Vargas, Yang Weiming, Pan Jianbo, Wen Bo, Dou Yongchao, Jiang Wen, Liao Yuxing, Shi Zhiao, Terekhanova Nadezhda V, Cao Song, Lu Rita Jui-Hsien, Li Yize, Liu Ruiyang, Zhu Houxiang, Ronning Peter, Wu Yige, Wyczalkowski Matthew A, Easwaran Hariharan, Danilova Ludmila, Mer Arvind Singh, Yoo Seungyeul, Wang Joshua M, Liu Wenke, Haibe-Kains Benjamin, Thiagarajan Mathangi, Jewell Scott D, Hostetter Galen, Newton Chelsea J, Li Qing Kay, Roehrl Michael H, Fenyö David, Wang Pei, Nesvizhskii Alexey I, Mani D R, Omenn Gilbert S, Boja Emily S, Mesri Mehdi, Robles Ana I, Rodriguez Henry, Bathe Oliver F, Chan Daniel W, Hruban Ralph H, Ding Li, Zhang Bing, Zhang Hui
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient survival. Toward understanding the underlying molecular alterations that drive PDAC oncogenesis, we conducted comprehensive proteogenomic analysis of 140 pancreatic cancers, 67 normal adjacent tissues, and 9 normal pancreatic ductal tissues. Proteomic, phosphoproteomic, and glycoproteomic analyses were used to characterize...
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