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Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

5 Sept 2018

Abstract excerpt

Offspring of women with gestational diabetes mellitus (GDM) are at increased risk of developing metabolic disease, potentially mediated by epigenetic mechanisms. We recruited 608 GDM and 626 control offspring from the Danish National Birth Cohort, aged between 9 and 16 years. DNA methylation profiles were measured in peripheral blood of 93 GDM offspring and 95 controls using the Illumina HumanMethylation450...

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PMID: 30185669
DOI: 10.1172/jci.insight.122572

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