Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells.

Cells - 13 Nov 2022

Li Li, Sheng Kai, Mannarino Matthew, Jarzem Peter, Cherif Hosni, Haglund Lisbet

Abstract excerpt

Human mesenchymal stem cell (hMSC) and extracellular vesicle (EV) therapy is a promising treatment for discogenic low back pain (LBP). Although promising, major obstacles remain to be overcome. Cellular senescence reduces self-renewal and multipotent potentials, and the senescence-associated secretory phenotype creates an inflammatory environment negatively affecting tissue homeostasis. Reducing senescence could...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Extracellular Vesicles
Share to Intervertebral Disc

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mesenchymal Stem Cells

Share to Phenotype

Share to Proteoglycans

Source

Open in PubMed Open full text

Identifiers

PMID: 36429018
DOI: 10.3390/cells11223589
PMCID: PMC9688801

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

o-Vanillin Modulates Cell Phenotype and Extracellular Vesicles of Human Mesenchymal Stem Cells and Intervertebral Disc Cells.PMID 36429018Read ↗

Small extracellular vesicles from mesenchymal stromal cells: the next therapeutic paradigm for musculoskeletal disordersSemantic proximity Read ↗

Extracellular vesicles from human mesenchymal stem cells expedite chondrogenesis in 3D human degenerative disc cell culturesSemantic proximity Read ↗

Therapeutic strategies for intervertebral disc degeneration: Extracellular vesicles and microRNAs derived from mesenchymal stem cellsSemantic proximity Read ↗

Cell and Cell-Free Therapies to Counteract Human Premature and Physiological Aging: MSCs Come to LightSemantic proximity Read ↗

Senotherapeutic drugs for human intervertebral disc degeneration and low back painSemantic proximity Read ↗

Toll-Like Receptor 2 Induced Senescence in Intervertebral Disc Cells of Patients with Back Pain can be Attenuated by o-VanilinSemantic proximity Read ↗

Nanoscale Treatment of Intervertebral Disc Degeneration: Mesenchymal Stem Cell Exosome TransplantationSemantic proximity Read ↗

Small Extracellular Vesicles from Human Bone Marrow Mesenchymal Stromal Cells enhance migration and regulate gene expression of reparative mechanisms in human dermal fibroblastsSemantic proximity Read ↗

The isolation and characterisation of equine bone marrow stem cell derived extracellular vesicles – evidence of an anti-inflammatory action on chondrocytes.Semantic proximity Read ↗

Extracellular vesicle bioactivity and potential clinical utility is determined by mesenchymal stromal cell clonal subtypeSemantic proximity Read ↗

Mesenchymal Stem Cell-Derived Exosomes and Intervertebral Disc Regeneration: ReviewSemantic proximity Read ↗

Stem Cells and Exosomes: New Therapies for Intervertebral Disc DegenerationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.