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Article

The impact of variant classification on the clinical management of hereditary cancer syndromes.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Feb 2019

Turner Scott A, Rao Smita K, Morgan R Hayes, Vnencak-Jones Cindy L, Wiesner Georgia L

Abstract excerpt

PURPOSE: The reclassification of genetic variants poses a significant challenge for laboratories and clinicians. Variant review has resulted in the reclassification of variants of unknown significance as well as the reclassification of previously established pathogenic and likely pathogenic variants. These reclassifications have the potential to alter the clinical management of patients with hereditary cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29875428
DOI: 10.1038/s41436-018-0063-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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